VDR gene variants have been associated with worse metabolic profile in the general population. The Apa1 In this study, we examine the association of the CDX2 VDR polymorphism (rs11568820) located in the 5-untranslated region of the gene, and VDR haplotypes, including this polymorphism, with colon and rectal cancer using data from two large case-control Epidemiological studies suggest that it may be associated with vitamin D receptor gene (VDR) polymorphisms. Association of VDR polymorphisms (Taq I and Bsm I) with prostate cancer: a new meta-analysis - Sheng Liu, Hairong Cai, Weisong Cheng, In human, VDR gene is found on the chromosome 12 (12q12-q14) with 11 exons and spans ~ 75kb gen-omic DNA. The reason for this is because they claim that VDR Bsm and Taq "track" each other for the vast majority of people, i.e. Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. Genetic Genie just generates the list based on whatever Yasko says about the SNPs. We found that several VDR variants FokI, BsmI, and TaqI polymorphisms are related to ASD. Materials and methods. Abstract. Serum levels of 1a, 25-Dihydroxyvitamin in primary open-angle glaucoma patients were lower than in age-matched controls. VDR Tak and VDR Bsm are usually inverse from eachother. Relao de tabelas e descries do Microsiga Protheus A00 (Territrio x Nvel do Agrup.) For each of the four polymorphisms, we explored the significance of the associations for the The human VDR is a product of a chromosomal gene which locates on chromosome 12 at 12q13-14 [22]. Here are all the uppercase one-, two-, and three-letter shortcuts on Wikipedia. In this study, influence However more recently they no longer test VDR Bsm, and instead only test VDR Taq. The VDR TaqI polymorphism located within exon 9 of the gene affects mRNA stability, therefore regulating VDR protein levels and the biological function of vitamin D. Haplotype analysis investigating the interaction between VDR BsmI, ApaI, and TaqI polymorphisms and bone health strongly associated the BsmI A allele and TaqI C allele with osteoporosis risk. Kelly A, Nov 9, 2017 #10. taiyang New Member. DNA [email protected] Master mix (Promega, containing, dNTPs, Buffer MgCl 2 and Taq pol. It also has a flow chart of Vitamin D in the body showing the 5 genes which can restrict the amount of vitamin D which gets to cells, only 1 of which is noticed by the standard Vitamin D test. However, this is not always the case. BackgroundThe disparity in prevalence of infectious diseases across the globe is common knowledge. VDR Bsm: rs1544410: T: TT +/+ VDR Bsm/Taq mediates an increase in dopamine production in response to Vitamin D (VDR is an abbreviation for Vitamin D Receptor). +/+ MTHFR A1298C, VDR Taq, BHMT-08, CBS A360A +/-COMT V158M, COMT H62H, MTRR A66G, BHMT-02, BHMT-04, AHCY-01, AHCY-02, AHCY-19; I decided to put this blog post together to summarize how each of these things specifically affects my body. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. Results: Odds ratio (OR) analysis found that VDR-BsmI and VDR-TaqI polymorphic alleles were both associated with increased risk of cognitive decline (OR = 1.55 and OR = 1.49, respectively). +/-VDR taq. The allele digested by the restriction enzyme was denoted by a lower letter, whereas that not digested was indicated by a capital letter. She first said adrenal fatigue and as we talked more about my family history, she recommended me get tested for the mthfr mutation. A. Vitamin D3 (cholecalciferol) is synthesized in the skin. Proc Amer Assoc Cancer Res, Volume 46, 2005 5813 Background: Circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) has potent effects on cell growth and differentiation via binding with the nuclear vitamin D receptor (VDR). Im going to tackle the homozygous SNPs first, the ones where I have two copies of the bad SNP. Another study shows that Taq-I polymorphism leads to an increase in the risk of ischemic stroke in a gender specific manner through impaired lipid [ 22 ]. Background: This study was designed to evaluate the influence of vitamin D receptor (VDR) gene polymorphisms on systemic lupus erythematosus (SLE) susceptibility. Vitamin D, together with its nuclear receptor (VDR), plays an important role in modulating the immune response, decreasing the inflammatory process. 0.8 mmol/l of each dNTP, 1.5 U Purpose The objective of the present meta-analysis was to evaluate the association between TaqI (rs731236), ApaI (rs7975232) and BsmI (rs1544410) polymorphisms of the VDR gene and lumbar spine pathologies such as lumbar disc herniation and lumbar disc degeneration. However, associations of VDR polymorphisms with skin cancer risk remain insufficiently characterized 30,31,36. my serum folate level 12.1ug serum b12 1039 ng/L The VDR gene consists of 11 exons that together with introns span approximately 7 kB of genomic DNA and code for VDR protein made up of 427 aminoacides. I also had homozygous for VDR Bsm, MTRR H595Y, MTRR K350A and CBS C699T. Some polymorphisms of the VDR gene, such as BsmI (G>A rs1544410), ApaI (G>T rs7975232), and TaqI (T>C rs731236) could affect its stability and mRNA transcription activity, while FokI T>C (rs2228570) gives a Previous studies have investigated the associations between VDR single nucleotide polymorphisms (SNPs) (polymorphisms at BsmI, ApaI, FokI, or TaqI cutting sites) and urolithiasis in different populations. Our study suggests that, Bsm 1 and Taq 1 polymorphisms of the VDR gene associated with the prevalence of T1DM. -/-I would love more info on where would be a good place to live. The relation between FokI (ff) genotype polymorphism and increased level of serum 1,25(OH)D3 in ASD patients is a very significant finding. The most studied VDR gene polymor-phisms are BsmI, ApaI, FokI, and TaqI. VDR polymorphisms are associated with susceptibility to development of heart failure in Chinese patients. The aim of the study was the investigation of the relevance of rs731236; Thermus aquaticus I (TaqI), rs7975232; VDR Taq AA augments (increases) VDR gene expression according to a study, and protects against MS according to another study. Apa I and Taq I polymorphisms of VDR (vitamin D receptor) gene in association with susceptibility to tuberculosis in the Romanian population Received for publication, October 15, 2011 BsmI, ApaI and TaqI being most intensively investigated [13-15]. How is vitamin D from sunlight different than dietary vitamin D? Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in innate immunity. The PCR steps comprisedof a hot start at 95 C for 10 minutes followed by 45 cycles of 94 C for 15 seconds and 60 C for 1 Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies and the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers. Four polymorphisms were included in the metaanalysis: VDR TaqI (rs731236), VDR BsmI (rs1544410), VDR FokI (rs2228570), and VDR ApaI (rs7975232). The aim of the present study was to determine intron 8 Bsm I (rs1544410) VDR gene polymorphism in association with TMJ-ID in Kashmiri population. Toll-like (TLRs) and vitamin D receptors (VDRs) play essential role in immunity and gut microbiome determination. Background: The vitamin D receptor ( VDR ) gene is important to human stature, as it mediates metabolic pathways, calcium homeostasis, and phosphate homeostasis, which influence growth. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. This study was conducted to investigate the association of VDR gene polymorphism with the risk of calcium nephrolithiasis.Methods: We investigated the VDR ApaI, BsmI and TaqI polymorphisms, in 1988). mechanism by which the VDR gene influences bone mass has not been fully elucidated. VDR Fok has been associated with blood sugar issues and poor pancreatic activity. A01 (Exceo Territoriais x Agrup.) A pooled analysis was performed using the Stata software. a mutation in one SNP corresponds to a mutation in another. VDR Tak and VDR Bsm are usually inverse from eachother. The VDR gene provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond to vitamin D. This vitamin can be acquired from foods in the diet or made in the body with help from sunlight exposure. Methods: We examined the relationship between VDR and adult height in 1873 white subjects from 406 nuclear families. (vdR) mediates most of the genomic effects of 1,25(OH) 2 d 3, vdR might represent a susceptibility gene for vitiligo (14). Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and SNPs of VDR gene (Apa-1 and Taq-1) were associated with the risk of DED. So if there is a positive VDR Tak, there would be a negative VDR Bsm. Moreover, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I BB genotypes . Numerous studies disclosed the independent role of genetic polymorphisms in this pathway, vitamin D And was heterozygous for COMT H62H and COMT V158M VDR TaqI and VDR BsmI are associated with autoimmune thyroid disease. Vitamin D, besides its role in calcium-phosphorus metabolism, turned out to play a significant immunomodulating function. Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in innate immunity. VDR Bsm -/- and VDR Taq +/+ are basically the same thing. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. The VDR gene consists of 11 exons that together with introns span approximately 7 kB of genomic DNA and code for VDR protein made up of 427 aminoacides. 3531 Background: Microbial translocation from the intestinal lumen into the blood circulation is significantly linked to intestinal dysbiosis; thus, leading to colorectal cancer (CRC), disease progression and decreased survival. BsmI-ApaI VDR haplotypes with theseverity ofthepathology thatwasmore significant inthe older(>63.6years) thaninthe youngersubjects[20].However,differentlyfromthemajority ofthestudies, inthe Japanese studytheBsmIand ApaIRFLPswerenotinLD. Type 1 diabetes mellitus (T1DM) is a T cell mediated autoimmune disease. Homozygous mutations MAO-A R297R BHMT-08. Studies suggest that polymorphisms of the vitamin D receptor (VDR) gene may influence colorectal cancer risk. The study was Three SNPs in the VDR gene ( Bsm I, Taq I and Apa I) are in strong linkage disequilibrium and have previously been associated with breast cancer risk Methods: All eligible investigations were identified, the number of the various genotypes in the case and control groups were reviewed. Haplotype analysis of three loci was applied to the obtained genotypes. In humans, VDR gene is mapped at chromosome 12 (12q12-q14), it has 11 exons and spans ~75 kb of genomic DNA. Thanks! Many single nucleotides polymorphisms (SNPs) have been identified in VDR gene, including the Bsm I (G/A) polymorphism. Background VDR gene polymorphisms have been reported to be associated with an increased Purpose . The other gene of interest was TNFSF11, which encodes RANKL (14,15). Numerous studies disclosed the independent role of genetic polymorphisms in this pathway, vitamin D The SNPs of VDR mostly studied Taq I, Apa I, Fok I, Bsm I are Even paternal VDR polymorphism can be a causative factor for ASD in the offspring. Identified genotypes of Fok-1(rs2228570) are FF, Ff, ff; Bsm-I (rs1544410) are BB, Bb, bb; Taq I (rs731236) genotypes are TT, Tt, tt, and Apa-I (rs79752320 are AA, Aa, and aa). The four VDR SNPs: Taq-I(rs731236), Bsm-I(rs1544410), Apa-I(rs7975232), and Fok-I(rs10735810) were evaluated by allelic discrimination real-time PCR using predesigned TaqMan genotyping assays (Applied Biosystems, Foster City, CA). Background: VDR gene polymorphisms have been reported to be associated with an increased risk of lumbar spine The Bsm I (rs1544410) restriction site is in intron 8 of VDR; this polymorphism does not affect the amino acid sequence of VDR, but many studies have suggested that it is closely related to prostate cancer risk. planned to determine the genotypes distribution and correlation of VDR alleles with T2D patients. Vitamin D receptor (VDR) gene polymorphisms such as Fok I, Bsm I, Apa I, and Taq I are also associated with different courses of viral infections. It must be emphasized that 17. The VDR 5 polymorphism Fok I seemed to be associated with peak bone mass [20]. Red labs have a specific VDR genetics test where they test the two VDR SNPs Fok and Bsm. In humans, VDR is a product of a single gene located on the long arm of the chro-mosome 12 (12q12-q14) which cDNA was cloned in 1988 (Baker et al. No significant association of Bsm-1 and Fok-1 in VDR gene demonstrated significant effect in the incidence of DED. Examination of the A02 (Exceo por Nveis do Agrupado) A03 (Sequenciador) A04 (Sequencia x Agrupador) A05 (Script x Rotina) A06 (Item Script Validao) A08 (Agrup. . stage III CRC patients and correlate the presence of TLR and VDR genetic variants with microbial DNA fragments at risk of CRC development and progression. We investigated the genotype and haplotype distribution of the Bsm-I (rs1544410), Apa-I (rs7975232), and Taq-I (rs731236) VDR gene polymorphisms in PCOS and non-hirsute women from southern Brazil. David Moorefield, Nov 13, 2017 #1. mmarston and Janet Shold like this. Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality. There was no statistically significant relationship between VDR gene and Bsm I, Fok I, Apa I, Taq I polymorphisms and vitamin D levels in inactive hepatitis B carriers and control group (p>0.05). However, this is not always the case. Genotyping of Taq-I (rs731236) and Bsm-I (rs1544410) was Conclusion Vitamin D deficiency is highly prevalent both among control population as well as in chronic hepatitis patients. The study was In 19962001, 108 (age 513, mean 6.9), and in 20082010 231 (age 511, mean 7.9) children from Poland were tested by posturography and blood-lead concentration (B-Pb; medians 50 and 36 g/L, respectively). Polymorphisms in such receptors Vitamin D was found to suppress the incidence of diabetes when bind to its receptor (VDR), probably by suppressing T cell activations. Good idea to monitor: Yasko did or still does report the contradictory versions as being the "risky" version, even though it makes no sense at all. This would seem to mesh with the view that Bsm TT/Taq GG is the riskier/slower version. A total of 65 (14929 samples), 31 (7697 samples), 18 (3617 samples), and 26 (5353 samples) studies for Bsm I, Apa I, Fok I, and Taq I polymorphisms, respectively, were included. Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. Enable Popups to find out what they are by hovering over them. The studies were association studies with osteoporotic cases and The meta-analysis involved 14, seven, seven and three studies for BsmI, TaqI, ApaI and FokI polymorphisms, respectively. 2012;18:661-6. Roles of VDR polymorphisms in melanoma were evaluated in some recent studies and meta-analyses 30-37. VDR Tak and VDR Bsm are usually inverse from eachother. Different biochemical parameters like random blood sugar, Urea, Creatinine, Triglyceride, ALT, Uric Acid were also assayed and finally correlated them with diabetes and VDR SNPs. Vitamin D receptor (VDR) plays a key role in calcium metabolism, and is closely related to urinary stone formation (urolithiasis). Determining molecular markers for osteoporosis may be valuable for improving the quality of life of affected elderly patients by aiding in early detection and disease management. Bsm = Taq (in most cases) Yasko used to test the 3 VDR SNPs Fok, Bsm and Taq. With COMT V158M + and a VDR Taq + status, the body may have further trouble tolerating methyl donors. This is a dictionary file with all the words ever It must be emphasized that A meta-analysis regarding BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and their associations with osteoporosis in females is reported. This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency. Background In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children. Background: This study was designed to evaluate the influence of vitamin D receptor (VDR) gene polymorphisms on systemic lupus erythematosus (SLE) susceptibility. The four major VDR polymorphisms (Bsm 1, Fok 1, Taq 1, and Apa1) were genotyped using the polymerase chain reaction- restriction fragment length polymorphism (PCR RFLP) method. JanSz Gold. Aktan S, Bagci H. Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients. Until now four single nucleotide polymorphisms of vitamin D receptor gene ( VDR ), rs2228570 ( Fok I), rs1544410 ( Bsm I), rs7975232 ( Apa I), and rs731236 ( Taq I), have been studied in autoimmune thyroid disorders, with conflicting results. This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies and the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. Epidemiological studies suggest that it may be associated with vitamin D receptor gene ( VDR) polymorphisms. VDR Tak and VDR Bsm are usually inverse from each other. 3531 Background: Microbial translocation from the intestinal lumen into the blood circulation is significantly linked to intestinal dysbiosis; thus, leading to colorectal cancer (CRC), disease progression and decreased survival. and VDR (TaqI, ApaI, FokI and BsmI) genes. and VDR (TaqI, ApaI, FokI and BsmI) genes. 63, No. +/-MTHFR 1298C +/+ MTHFR C677T -/-CBS C699T. In addition, biochemical markers of CKD-MBD were measured to determine their associations with the four VDR polymorphisms. It also lists 7 ways to improve your vitamin D receptor. The (+/+) form is less active, so you tend to be low in dopamine. There are several VDR genotypes.161 The most important of these regarding cancer is Bsm I,162, 163 which has 3 variants: BB, Bb, and bb. amino acid sequence of VDR, but many studies have suggested that it is closely related to prostate cancer risk.2023 The Taq I (rs731236) polymorphism is a syn-onymous mutation located in VDR exon 9, which is also associated with prostate cancer risk.20,2429 Several studies have investigated the potential risk of Taq I (rs731236) and Bsm Although several studies between osteoporosis and VDR gene http://cebp.aacrjournals.org/content/18/11/2874.full (See section entitled "DNA Extraction and Polymorphisms in such receptors With respect to VDR SNPs effect on vitiligo phenotypes, two studies investigating the relationship of the VDR Fok I, Bsm I, and Taq I with clinical characteristics of vitiligo failed to demonstrate a link between the studied VDR SNPs and age at disease onset (22,26).In contrast, our intra-patient analysis showed that the VDR Fok I SNPs could have a protective effect against 5, May 2009 191 In addition, we also compared the VDR (FokI, BsmI and TaqI) genotypes with different clinical parameters of T2DM but could not obtain Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. and VDR genotypes modify the effect. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched healthy individuals. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. The VDR test quantifies just one of those genes. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for But basically the research shows small effects in either direction. Background Polymorphisms of the vitamin D receptor (VDR) gene have been linked to both multiple sclerosis (MS) and osteoporosis. A pooled analysis was performed using the Stata software. However, this is not always the case. Regulatory Role of Vitamin D Receptor Gene Variants of Bsm I, Apa I, Taq I, and Fok I Polymorphisms on Macrophage Phagocytosis and Lymphoproliferative Response to Mycobacterium tuberculosis Antigen in Pulmonary Tuberculosis VDR is a ligand- males (mean age SE: 26.5 1.7 years). psw.txt - Free ebook download as Text File (.txt), PDF File (.pdf) or read book online for free. The BsmI, ApaI and TaqI polymorphisms of VDR were studied using previously tested primers to amplify the first part of intron 8 for BsmI, and a fragment of intron 8/exon 9 for ApaI and TaqI . VDR Bsm VDR Taq MTRR A66G MTRR K350A AHCY-01 AHCY-19 CBS C699T CBS A360A. The health of those squarely in the middle, with single mutations in both Bsm/Taq and Fokthe most common combo in both ME/CFS patients and healthy controlsis also improving on GcMAF and Nexavir, according to de Meirleir, though not as dramatically as those with double mutations in Bsm/Taq and wild type in Fok. Differences inethnicity, inclusion criteria whencomparingthesame ethnicgroup, and a +/-CBS A360A. Methods: All eligible investigations were identified, the number of the various genotypes in the case and control groups were reviewed. [edited] Two different questions are being asked. Another study shows that Taq-I polymorphism leads to an increase in the risk of ischemic stroke in a gender specific manner through impaired lipid [ 22 ]. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. VDR gene polymorphisms was determined by PCR-RFLP. Dictionary - Free ebook download as Text File (.txt), PDF File (.pdf) or read book online for free. At present, no study examined VDR polymorphisms and VDR expression in melanoma cells of excised tissues from patients. The most studied VDR gene polymorphisms are- I Bsm (rs1544410), ApaI (rs7975232), FokI (rs10735810), and TaqI (rs731236).Although several studies between osteoporosis and VDR gene polymorphisms have been published, the Typical. There is no independent risk associated with either the T or the C allele of the SNP TaqI in the VDR gene, sometimes termed TaqI. U4a- most people now carrying that haplogroup have settled in western Russia, which is where my mother was born. The VDR polymorphism can play a role in the development of ASD by influencing the action pathway of vitamin D . Taq I rs731236 Metabolic syndrome, Obesity, breast cancer, new onset diabetes at transplant, Bsm I rs1544410 Metabolic syndrome, Obesity, Breast cancer, BPH, Prostate cancer, allograft survival in renal transplant VDR gene polymorphisms were also found associated with type I diabetes in a Taiwanese population. AAL|AALBORG|Denmark AES|AALESUND VIGRA|Norway AAR|AARHUS TIRSTRUP|Denmark ABD|ABADAN|Iran In the present study, the association between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) and tumour necrosis factor superfamily number 11 (TNFSF11) genes and the VDR gene polymorphisms Bsm I, Taq I, and Apa I, located at the VDR 3 untranslated region, were associated with low bone mineral density and osteoporosis [6, 19]. Objectives To determine whether ApaI, BsmI, FokI or TaqI polymorphisms in vitamin D receptor (VDR) gene confer susceptibility to psoriasis.. Methods All related association studies published before January 2012 were retrieved and eligible ones were included in our meta-analysis. The VDR gene, located on chromosome12q13.11, has been found to contain more than 200 single-nucleotide poly-morphisms (SNPs) (15). VDR polymorphisms were detected by using real-time PCR. The VDR gene is located on the long (q) arm of chromosome 12 with 11 exons.11 Several polymorphisms have been identified in VDR gene that has functional significance. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. Many single nucleotides polymorphisms have been identified in VDR gene including a Fok 1 restriction fragment length polymorphism in exon 2, Bsm 1 and Apa1 polymorphisms in the intron between exons 8 and 9, Taq 1 in exon 9. However, this is not always the case. In the present meta-analysis, four common VDR gene polymorphisms (BsmI, ApaI, FokI, and TaqI) were included. Rather the risk depends on the association of TaqI with the other VDR SNPs BsmI and ApaI. However, this is not always the case. I ran my own DNA and showed that I am VDR taq +/- and VDR bsm +/- along with another couple of heterozygous and homozygous mutations that affect how D is processed. 1988). Four polymorphisms were included in the metaanalysis: VDR TaqI (rs731236), VDR BsmI (rs1544410), VDR FokI (rs2228570), and VDR ApaI (rs7975232). Bsm I polymorphism [13-18]. Purpose: The objective of the present meta-analysis was to evaluate the association between TaqI (rs731236), ApaI (rs7975232) and BsmI (rs1544410) polymorphisms of the VDR gene and lumbar spine pathologies such as lumbar disc herniation and lumbar disc degeneration.